Positive- and negative-ion mass spectrometry and rapid clean-up of 19 phenothiazines was written by Ishikawa, Yasunobu;Suzuki, Osamu;Hattori, Hideki. And the article was included in Forensic Science International in 1990.Product Details of 316-81-4 This article mentions the following:
Pos.-ion electron impact (PIEI), pos.-ion chem. ionization (PICI), and neg.-ion chem. ionization (NICI) mass spectra of 19 phenothiazines are presented. In the PIEI mode, peaks due to M, M minus side chain (M – R1), M – R1 + H, and side chain itself (R1) appeared for most compounds The M – R1 ions were very useful for drug screening. In the PICI mode, most spectra showed base or intense peaks due to M + H, and small peaks due to M + C2H5; peaks due to M – R1 also appeared in many compounds In the NICI mode, fragmentation modes were different in different compound groups; mol. or [M – H]– quasimol. anions appeared in many compounds with aliphatic side chains. Anions at m/z 98 and 115 were characteristic for compounds with (N-methylpiperazinyl)propyl side chains. Selected ion monitoring in the PIEI mode generally gave much higher sensitivity than in the PICI and NICI modes. Phenothiazines present in urine or plasma could be rapidly isolated by use of Sep-Pak C18 cartridges. Thirteen of 19 phenothaizines could be detected by HP-17 wide-bore capillary gas chromatog. with satisfactory separation from impurities in their underivatized forms. In the experiment, the researchers used many compounds, for example, N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide (cas: 316-81-4Product Details of 316-81-4).
N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide (cas: 316-81-4) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Product Details of 316-81-4
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics