Facilitation of delayed spontaneous alternation behavior in adult rats following early hydroxyzine treatment: differential sensitivity in late infancy was written by Isseroff, Ami. And the article was included in Psychopharmacology (Berlin, Germany) in 1980.Computed Properties of C21H29Cl3N2O2 This article mentions the following:
When tested in adulthood, male rats that had been treated daily with 50 mg/kg hydroxyzine-HCl (I) [2192-20-3] s.c. at 10-29 or 23-29 days of age were facilitated in performance of delayed spontaneous alternation relative to saline-injected rats. Treatment at 10-16 days of age did not produce significant facilitation in the delay task, nor were there any significant differences between groups in spontaneous alternation with no intertrial delay. The facilitative effect may be attributable to anomalies in areas, such as the limbic system, that continue to develop postnatally and mature in late infancy. In the experiment, the researchers used many compounds, for example, 2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)ethanol dihydrochloride (cas: 2192-20-3Computed Properties of C21H29Cl3N2O2).
2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)ethanol dihydrochloride (cas: 2192-20-3) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Computed Properties of C21H29Cl3N2O2
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics