Reduction of 2,5-dioxopiperazines with lithium aluminum hydride was written by Langenbeck, Wolfgang;Augustin, Manfred;Boehm, Ralf;Hoffmann, Siegfried. And the article was included in Journal fuer Praktische Chemie (Leipzig) in 1964.Synthetic Route of C4H12Cl2N2 This article mentions the following:
2,5-Di-oxopiperazines added to excess LiAlH4 in dry tetrahydrofuran, the mixture refluxed 165 hrs., the excess LiAlH4 decomposed with dilute H2SO4, the solution extracted with Et2O, the raffinate alkalinized with KOH and steam-distilled, the distillate acidified with HCl and evaporated, and the residue crystallized from EtOH or EtOH-Et2O gave the piperazine hydrochlorides (substituents and % yield given): none, 40; 1,4-dimethyl, 62; 1,4-dibenzyl (free base m. 92°), 57; 3,6-dimethyl, 55; 3,6-dimethyl, 38; 3,6-diisopropyl, 38; and 3,6-diisobutyl, 48 (250 hrs. reflux). In the experiment, the researchers used many compounds, for example, Piperazine Dihydrochloride (cas: 142-64-3Synthetic Route of C4H12Cl2N2).
Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Synthetic Route of C4H12Cl2N2
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics