Preparation and quality control of lomerizine hydrochloride capsules was written by Liu, Min-hong;Ding, Jian;Yao, Xiao-min;Li, Chen. And the article was included in Yaoxue Jinzhan in 2005.Reference of 101477-54-7 This article mentions the following:
A method for the preparation and quality control of lomerizine hydrochloride capsules was established. The preparation method for the capsules has been improved and the stability was also studied. The amount of lomerizine hydrochloride in capsules was determined by HPLC with an average recovery 99.7% (RSD=0.64%). The preparation procedure for lomerizine hydrochloride capsules is practicable and the quality control methods are reliable. In the experiment, the researchers used many compounds, for example, 1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7Reference of 101477-54-7).
1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Reference of 101477-54-7
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics