Effects of 1-[bis(4-fluorophenyl)methyl]-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (KB-2796) on cerebral circulation in dogs was written by Morita, Tominori;Iwamoto, Takahiro;Harada, Kengo;Hara, Hideaki;Sukamoto, Takayuki;Ito, Keizo;Nurimoto, Seiichi. And the article was included in Oyo Yakuri in 1993.Application of 101477-54-7 This article mentions the following:
The effects of 1-[bis(4-fluorophenyl)methyl]-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (KB-2796, I), a new calcium antagonist, on cerebral circulation were studied in anesthetized dogs. KB-2796 increased the vertebral blood flow when injected into the vertebral artery (3-300 μg/kg) or into the vein (30-1,000 μg/kg) or introduced into the duodenum (3 or 10 mg/kg) in anesthetized dogs. KB-2796 was more potent than flunarizine and papaverine in increasing the flow rate. The duration of action of KB-2796 was longer than that of papaverine and compatible to that of flunarizine. The effect of KB-2796 injected into the vertebral artery in increasing the vertebral blood flow was not affected by pretreatment with propranolol, atropine, chlorpheniramine or aminophylline in anesthetized dogs. Furthermore, KB-2796 (i.v.) did not potentiate the effect of adenosine. KB-2796 (0.1 and 0.3 mg/kg, i.v.) and flunarizine (1 mg/kg, i.v.) increased the cerebral blood flow without modifying cerebral oxygen consumption in pancronium-immobilized anesthetized dogs. The results suggest that KB-2796 increases the cerebral blood flow presumably through vasodilation of the cerebral vessels by blocking calcium channels. In the experiment, the researchers used many compounds, for example, 1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7Application of 101477-54-7).
1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Application of 101477-54-7
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics