Spectrophotometric determination of some phenothiazine derivatives in pharmaceutical preparations was written by Revanasiddappa, H.D.;Ramappa, P.G.. And the article was included in Eastern Pharmacist in 1995.Related Products of 316-81-4 This article mentions the following:
A simple, accurate and rapid method for the quant. determination of phenothiazine drugs in either the bulk or in pharmaceuticals is based on the development of colored compounds with vanadoboric acid in acid medium. The reaction is suggested to proceed via oxidation of the phenothiazine nucleus into a semiquinonoid radical. A study of the effect of commonly associated excipients revealed that they did not cause any interference. Statistical anal. of results indicates that the method is precise and accurate. In the experiment, the researchers used many compounds, for example, N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide (cas: 316-81-4Related Products of 316-81-4).
N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide (cas: 316-81-4) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Related Products of 316-81-4
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics