Radioimmunoassay of tricyclic antidepressant and some phenothiazine drugs in forensic toxicology was written by Robinson, Katherine;Smith, R. N.. And the article was included in Journal of Immunoassay in 1985.Application In Synthesis of N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide This article mentions the following:
A RIA for screening blood and urine for tricyclic antidepressant and some phenothiazine drugs in forensic toxicol. is described. The assay has a broad cross-reactivity that enables therapeutic or subtherapeutic levels of most tricyclic antidepressants and a number of phenothiazines in blood to be detected. The antiserum is com. available and the radioligand, a radioiodinated conjugate of N-acetyl-
N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide (cas: 316-81-4) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Application In Synthesis of N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics