Optimization of quantitative analysis of buclizine hydrochloride using UV spectrophotometry in bulk drug and dosage formulations was written by Siddiqui, Farhan Ahmed;Mirza, Agha Zeeshan;Zuberi, M. Hashim;Qureshi, Faiza. And the article was included in Medicinal Chemistry Research in 2011.Name: 1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride This article mentions the following:
Development and validation of an anal. spectral calibration method to quantify buclizine hydrochloride, which is a piperazine derivative and used as a single active principle in pharmaceutical forms were done. The quantification of buclizine hydrochloride was performed in the wavelength range of 218-226 nm at N = 6. The linear regression equation was constructed using relationship between concentration and absorbance at 218, 220, 222, 224, and 226 nm. The developed method was applied directly and easily to the anal. of the pharmaceutical tablet preparations Mean %RSD was found to be 0.6231% (Longifene tablet 25 mg). The method was completely validated and proven to be rugged. This validated UV spectrophotometric method is potentially useful for a routine laboratory anal. because of its simplicity, rapidity, sensitivity, precision, and accuracy. In the experiment, the researchers used many compounds, for example, 1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride (cas: 129-74-8Name: 1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride).
1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride (cas: 129-74-8) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Name: 1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics