Development of validated spectrofluorimetric method for the estimation of buclizine hydrochloride from the tablet dosage form was written by Suganthi, A.;Fathimunnisa, A.;Sumithra, S.;Ravi, T. K.. And the article was included in Indo American Journal of Pharmaceutical Research in 2016.Application of 129-74-8 This article mentions the following:
Buclizine hydrochloride from its tablet dosage form was estimated by developing a novel validated indirect spectrofluorimetric method. Here the Buclizine hydrochloride was derivatized into nitro compound using nitrating mixture with an aid of heat which showed good fluorescence in water at 446 nm after excited at 350 nm. The calibration graph showed linear over the range 200-1000 ng/mL. The assay of buclizine hydrochloride in marketed formulations was found to be 98.96 卤 0.1586. Recovery values were close to 100% with the % RSD values of 0.432% and 0.673% at 50% and 100% level resp. From the results of validation it was observed that the method was found to be simple, accurate, sensitive and reproducible. Hence the proposed method can be used for routine quality control anal. In the experiment, the researchers used many compounds, for example, 1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride (cas: 129-74-8Application of 129-74-8).
1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride (cas: 129-74-8) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Application of 129-74-8
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics