Antibiotic resistance patterns of Helicobacter pylori strains isolated from the Tibet Autonomous Region, China was written by Tang, Xiaoqiong;Wang, Zhonghua;Shen, Yalin;Song, Xiaona;Benghezal, Mohammed;Marshall, Barry J.;Tang, Hong;Li, Hong. And the article was included in BMC Microbiology in 2022.COA of Formula: C43H58N4O12 This article mentions the following:
The prevalence of Helicobacter pylori antibiotic susceptibility in the Tibet Autonomous Region, China is not determined This study aimed to evaluate the antibiotic resistance patterns of H. pylori isolates there. A total of 153 (38.5%) H. pylori strains were successfully isolated from 397 patients in People’s Hospital of Tibet Autonomous Region, China. The overall resistance rates were as follows: clarithromycin (27.4%), levofloxacin (31.3%), metronidazole (86.2%), amoxicillin (15.6%), tetracycline (0%), furazolidone (0.6%), and rifampicin (73.2%). Only 2.0% of H. pylori isolates were susceptible to all tested antimicrobials, with mono resistance, dual resistance, triple resistance, quadruple resistance, and quintuple resistance being 18.3%, 44.4%, 18.3%, 12.4%, and 4.6%, resp. The resistance rates to levofloxacin (40.5%) and amoxicillin (21.5%) in strains isolated from female patients were significantly higher than those from male patients (21.6% and 9.5%, resp.). This study demonstrates high H. pylori resistance rates to clarithromycin, levofloxacin, metronidazole, and rifampicin, whereas moderate resistance to amoxicillin, and negligible resistant to tetracycline, and furazolidone in Tibet Autonomous Region, China. The high resistance to rifampicin warns further investigation of its derivative, rifabutin. In the experiment, the researchers used many compounds, for example, 8-(n-(4-methyl-1-piperazinyl)formidoyl)-rifomycins (cas: 13292-46-1COA of Formula: C43H58N4O12).
8-(n-(4-methyl-1-piperazinyl)formidoyl)-rifomycins (cas: 13292-46-1) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.COA of Formula: C43H58N4O12
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics