Derivatives of piperazine. I. Derivatives of 3,4,5-trimethoxybenzoylpiperazine, a new group of compounds with antiulcerogenic activity was written by Toldy, Lajos;Toth, Istvan;Borsy, Jozsef. And the article was included in Acta Chimica Academiae Scientiarum Hungaricae in 1966.COA of Formula: C14H20N2O3 This article mentions the following:
Thirty-nine 4-substituted 1-(3,4,5-trimethoxybenzoyl)piperazines, 11 1-substituted-4-hydroxyalkylpiperazines, 11 1,4-dihydroxyethylpiperazine esters, and 12 other compounds were synthesized and were tested for antiulcerogenic and sedative activities. 1-(3,4,5-Trimethoxybenzoyl)-4-(尾-hydroxypropyl)piperazine 3,4,5-trimethoxybenzoate was the most effective compound It had no anticholinergic properties and acted presumably by way of a central mechanism effected through the hypothalamus. 32 references. In the experiment, the researchers used many compounds, for example, Benzyl 4-(2-hydroxyethyl)piperazine-1-carboxylate (cas: 14000-67-0COA of Formula: C14H20N2O3).
Benzyl 4-(2-hydroxyethyl)piperazine-1-carboxylate (cas: 14000-67-0) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.COA of Formula: C14H20N2O3
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics