Overall Shape Constraint of Alternating 伪/尾-Hybrid Peptides Containing Bicyclic 尾-Proline was written by Wang, Siyuan;Otani, Yuko;Zhai, Luhan;Su, Aoze;Nara, Masayuki;Kawahata, Masatoshi;Yamaguchi, Kentaro;Sada, Akane;Ohki, Rieko;Ohwada, Tomohiko. And the article was included in Organic Letters in 2019.Formula: C30H30Cl2N4O4 This article mentions the following:
Our NMR, IR/Raman, CD spectroscopic, and X-ray crystallog. studies, as well as accelerated mol. dynamics simulations, showed that alternating hybrid 伪/尾-peptides containing a bicyclic 尾-proline surrogate form unique extended curved folds, regardless of the peptide length and solvent environment. It is suggested that extended 尾/PPII structures are preferred in the insulating 伪-alanine moieties between the rigid bicyclic 尾-proline structures. These hybrid peptides inhibit p53-MDM2 and p53-MDMX protein-protein interactions. In the experiment, the researchers used many compounds, for example, 4-(cis-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one (cas: 548472-68-0Formula: C30H30Cl2N4O4).
4-(cis-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one (cas: 548472-68-0) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Formula: C30H30Cl2N4O4
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics