Synthesis of lomerizine dihydrochloride was written by Xu, Changsheng;Chen, Guohua;Luo, Xiaochuan. And the article was included in Zhongguo Yaoke Daxue Xuebao in 2002.Formula: C27H32Cl2F2N2O3 This article mentions the following:
Lomerizine dihydrochloride, a calcium antagonist used as antimigraine drug, was synthesized by methylating pyrogallic acid with di-Me sulfate to afford 1,2,3-trimethoxybenzene, chloromethylating with paraformaldehyde to afford 2,3,4-trimethoxybenzyl chloride, substituting with bis(4-fluorobenzyl)methylpiperazine in presence of triethylamine. Lomerizine dihydrochloride was obtained with 43% overall yield from pyrogallic acid. The structure of the compound was confirmed by IR, 1H-NMR, MS, and elemental anal. In the experiment, the researchers used many compounds, for example, 1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7Formula: C27H32Cl2F2N2O3).
1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Formula: C27H32Cl2F2N2O3
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics