Determination of 50 antibiotic residues in drone pupa powder by liquid chromatography-tandem mass spectrometry was written by Yang, Wenquan;Zhang, Xiaoyan;Yao, Qian;Zhou, Yangjuan;Hu, Yawen;Wang, Maohua;Tang, Maozhi. And the article was included in Sepu in 2019.HPLC of Formula: 113617-63-3 This article mentions the following:
A method was established for the determination of 50 antibiotic residues (macrolides, quinolones, sulfonamides, tetracyclines, nitroimidazoles, lincomycin and chloramphenicol) in drone pupa powder by liquid chromatog.-tandem mass spectrometry (LC-MS/MS). The samples were extracted with perchloric acid and lead acetate solution, and the protein was precipitated The extraction solution was adjusted to pH 8 using dipotassium hydrogen phosphate, and then the solution was purified by solid phase extraction (SPE) and analyzed by LC-MS/MS. The target compounds in the drone pupa powder were determined quant. and quant. by using multiple reaction monitoring and pos. ion or neg. ion modes. The recoveries of the 50 antibiotics were in the range of 70.2-118.3%, and the relative standard deviations (RSDs) were 1.8-13.6%. The method is simple and selective, and can be suitable for the anal. and confirmation of veterinary drug residues in drone pupa powder. In the experiment, the researchers used many compounds, for example, 1-Cyclopropyl-7-(cis-3,5-dimethylpiperazin-1-yl)-5,6,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (cas: 113617-63-3HPLC of Formula: 113617-63-3).
1-Cyclopropyl-7-(cis-3,5-dimethylpiperazin-1-yl)-5,6,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (cas: 113617-63-3) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.HPLC of Formula: 113617-63-3
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics