Design and synthesis of C-12 dithiocarbamate andrographolide analogues as an anticancer agent was written by Arsakhant, Patcharee;Sirion, Uthaiwan;Chairoungdua, Arthit;Suksen, Kanoknetr;Piyachaturawat, Pawinee;Suksamrarn, Apichart;Saeeng, Rungnapha. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020.Application of 27469-60-9 This article mentions the following:
A series of 21 new analogs of C-12 dithiocarbamate andrographolide, I (R = morpholino, 4-phenylpiperazino, dibenzylamino, etc.), was designed and synthesized from natural andrographolide isolated from a common Thai plant, Andrographis paniculata. The reaction used to manipulate the andrographolide scaffold was conducted in one pot under mild reaction conditions. This avoided toxic catalysts and gave nearly quant. yields of the new analogs, generally without byproducts and can be easily scaled up for industrial processing. All new analogs were evaluated against nine cancer cell lines; some analogs exhibited greater selective cytotoxic activity to MCF-7 cancer cell than that of the parent andrographolide and cancer drugs. In the experiment, the researchers used many compounds, for example, 4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9Application of 27469-60-9).
4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Application of 27469-60-9
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics