Formulation and evaluation of orodispersible film of hydroxyzine hydrochloride was written by Jani, Rupal;Patel, Reeni;Shah, Pratik. And the article was included in World Journal of Pharmaceutical Research in 2015.Quality Control of 2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)ethanol dihydrochloride This article mentions the following:
In the present study, an attempt was made to develop orodispersible film of Hydroxyzine Hydrochloride by solvent casting method. Drugexcipients and excipients-excipients incompatibility study was carried out using fourier transform IR Spectroscopy (FTIR) which shows that drug-excipient and excipient-excipient were compatible to each other. Orodispersible film of Hydroxyzine Hydrochloride containing hydroxy Pr Me cellulose E5LV and hydroxy Pr Me cellulose E15LV were developed by solvent casting method using propylene glycol as a plasticizer and citric acid as a saliva stimulating agent. Batch H1 (hydroxy Pr Me cellulose E15LV 100 mg, citric acid 20 mg and propylene glycol 20% weight/weight) showed excellent appearance, transparency,% elongation 1.7 ± 0.30,tensile strength 35 ± 0.49, folding endurance 770 ± 3 and maximum drug entrapment 98.12%. This result revealed that presence of propylene glycol (20% weight/weight of polymer) was used which gave good physicochem. properties and citric acid (0.2%weight/weight of polymer) was rapid disintegration of orodispersible film. Stability studies of the optimized batch H1 showed that there were no significant changes in appearance, elasticity, folding endurance, thickness, drug entrapment, tensile strength and in vitro disintegration time after storage at 40 ± 2°C and 75 ± 5%RH for a one month. This approach suggested that the orodispersible film of Hydroxyzine Hydrochloride using hydroxy Pr Me cellulose E15LV, citric acid and propylene glycol gave rapid disintegration of orodispersible film and provide faster onset of action. In the experiment, the researchers used many compounds, for example, 2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)ethanol dihydrochloride (cas: 2192-20-3Quality Control of 2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)ethanol dihydrochloride).
2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)ethanol dihydrochloride (cas: 2192-20-3) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Quality Control of 2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)ethanol dihydrochloride
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics