Reusable Co-nanoparticles for general and selective N-alkylation of amines and ammonia with alcohols was written by Ma, Zhuang;Zhou, Bei;Li, Xinmin;Kadam, Ravishankar G.;Gawande, Manoj B.;Petr, Martin;Zboril, Radek;Beller, Matthias;Jagadeesh, Rajenahally V.. And the article was included in Chemical Science in 2022.Name: 4,4-Difluorobenzhydrylpiperazine This article mentions the following:
A general cobalt-catalyzed N-alkylation of amines with alcs. by borrowing hydrogen methodol. to afford alkylated amines I [R = Pr-n, cyclohexyl, Ph, etc.; R1 = Ph, 4-MeC6H4, 4-FC6H4, etc.] was reported. The optimal catalyst for this transformation was prepared by pyrolysis of a specific templated material, which was generated in situ by mixing cobalt salts, nitrogen ligands and colloidal silica and subsequent removal of silica. Applying this novel Co-nanoparticle-based material, >100 primary, secondary and tertiary amines including N-methylamines and selected drug mols. were conveniently prepared starting from inexpensive and easily accessible alcs. and amines or ammonia. In the experiment, the researchers used many compounds, for example, 4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9Name: 4,4-Difluorobenzhydrylpiperazine).
4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Name: 4,4-Difluorobenzhydrylpiperazine
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics