Neural induction with a dopaminergic phenotype from human pluripotent stem cells through a feeder-free floating aggregation culture was written by Morizane, Asuka;Doi, Daisuke;Takahashi, Jun. And the article was included in Methods in Molecular Biology (New York, NY, United States) in 2013.Application of 1062368-24-4 This article mentions the following:
Pluripotent stem cells are promising potential sources for cell replacement therapy and are useful research tools for exploring disease mechanisms. Neural cells are one of the cell types that have been most efficiently differentiated through several established protocols. This chapter describes the feeder-free floating aggregation culture system for the induction of dopaminergic neurons. This method is simple and highly efficient for the production of dopaminergic neurons. It has several advantages for application in clin. usage in comparison to the other protocols using either feeder cells or Matrigel. In the experiment, the researchers used many compounds, for example, 4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline (cas: 1062368-24-4Application of 1062368-24-4).
4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline (cas: 1062368-24-4) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Application of 1062368-24-4
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics