A simple and efficient synthesis of calcium channel blocker flunarizine was written by Narsaiah, A. Venkat;Kumar, J. Kranthi. And the article was included in Organic Chemistry: An Indian Journal in 2011.Quality Control of 4,4-Difluorobenzhydrylpiperazine This article mentions the following:
T-type calcium channel blocker and anti-ischemic drug 1-[bis(4-fluorophenyl)methyl]-4-cinnamylpiperazine synthesis was carried out in four steps with an average of 70% yield. This route is very convenient and can be applied for large scale preparation of Flunarizine with high yields. In the experiment, the researchers used many compounds, for example, 4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9Quality Control of 4,4-Difluorobenzhydrylpiperazine).
4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Quality Control of 4,4-Difluorobenzhydrylpiperazine
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics