Comparative dissolution of commercially available hydroxyzine hydrochloride tablets was written by Noory, Carol;Wolyniak, Cecilia;Ogger, Kathryn E.;Shah, Vinod P.. And the article was included in Drug Development and Industrial Pharmacy in 1992.Synthetic Route of C21H29Cl3N2O2 This article mentions the following:
A comparative dissolution study was conducted on com. available hydroxyzine-HCl tablets using USP Apparatus 2 (Paddle Method) at 50 rpm and two dissolution media: water and simulated intestinal fluid (SIF) and the USP recommended method employing the disintegration apparatus The dissolution characteristics of 22 samples of hydroxyzine-HCl tablets representing four dosage levels and seven manufacturers were profiled. The study illustrated that the Modified Disintegration apparatus is not able to distinguish slow dissolving formulations from fast dissolving formulation and, consequently, does not provide assurance of bioequivalence and does not perform as an adequate manufacturing control to insure lot to lot uniformity. In the experiment, the researchers used many compounds, for example, 2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)ethanol dihydrochloride (cas: 2192-20-3Synthetic Route of C21H29Cl3N2O2).
2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)ethanol dihydrochloride (cas: 2192-20-3) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.Synthetic Route of C21H29Cl3N2O2
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics