Synthesis and in-vitro study of novel (Z)-1-benzhydryl-4-cinnamylpiperazine derivatives as potential anticancer agents was written by Shivaprakash, S.;Kiran, K. R.;Diwakar, Latha;Reddy, G. Chandrasekara. And the article was included in International Journal of Pharmacy and Pharmaceutical Sciences in 2015.Related Products of 27469-60-9 This article mentions the following:
A series of novel (Z)-1-benzhydryl-4-cinnamylpiperazines I [R1 = R2 = Ph, 4-ClC6H4, 4-MeC6H4, 4-FC6H4; R1 = Ph, R2 = 4-ClC6H4, 4-BrC6H4; R3 = Ph, 4-MeOC6H4, 3,5-(MeO)2C6H3, piperonyl, etc.] was synthesized in six steps starting from the corresponding benzophenones R1COR2. The final step was Wittig condensation of the appropriate benzyltriphenylphosphonium halides R3CH2P+Ph3 X– (X = Cl, Br) with 1-benzhydryl-4-(formylmethyl)piperazines, which afforded pure (Z)-1-benzhydryl-4-cinnamylpiperazines I. The anticancer potential (MTT assay) of the synthesized compounds was tested against human cervical cancer (HeLa) and murine microglial (BV-2) cell lines. The compound I (R1 = R2 = 4-FC6H4; R3 = Ph) (cis-flunarizine) exhibited exceptionally superior activity against both HeLa and BV-2 cell lines with IC50 value of 13.23±3.51 μM and 23.1±4.12 μM, resp. Hence, this compound may be considered as a potential lead mol. for further development. In the experiment, the researchers used many compounds, for example, 4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9Related Products of 27469-60-9).
4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Related Products of 27469-60-9
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics