Synthesis of pyrazinamide Mannich bases and their antitubercular properties was written by Sriram, Dharmarajan;Yogeeswari, Perumal;Reddy, Sushma Pobba. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2006.Recommanded Product: 112811-57-1 This article mentions the following:
A series of pyrazinamide (PAZ) Mannich bases has been synthesized by reacting PAZ, formaldehyde, and various substituted piperazines using microwave irradiation with the yield ranging from 46% to 86%. The synthesized compounds were evaluated for antimycobacterial activity in vitro and in vivo against Mycobacterium tuberculosis H37Rv (MTB). Among the synthesized compounds, 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-4-((pyrazine-2-carboxamido)methyl)piperazinyl)-4-(oxo)-3-quinoline-carboxylic acid (I) was found to be the most active compound in vitro with MIC of 0.39 and 0.2 μg/mL against MTB and multidrug-resistant MTB, resp. In the in vivo animal model I decreased the bacterial load in lung and spleen tissues with 1.86 and 1.66-log10 protections, resp. In the experiment, the researchers used many compounds, for example, 1-Cyclopropyl-6-fluoro-8-methoxy-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 112811-57-1Recommanded Product: 112811-57-1).
1-Cyclopropyl-6-fluoro-8-methoxy-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 112811-57-1) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Recommanded Product: 112811-57-1
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics