Microwave-assisted synthesis of new 2-substituted phenyl-5-{N4-[bi-(4-fluoro phenyl)-methyl]-N1-methylene} piperazine-1,3,4-oxadiazoles was written by Zhang, Zhen;Mo, Song;Zhang, Gang;Shao, Xue-bei;Li, Qing-han;Yang, Xue-jun;Chen, Feng. And the article was included in Xinan Minzu Daxue Xuebao, Ziran Kexueban in 2017.Application In Synthesis of 4,4-Difluorobenzhydrylpiperazine This article mentions the following:
Objective: Eight new 2-substituted phenyl-5-{N4-[bi-(4-fluorophenyl)-methyl]-N1-methylene} piperazine-1,3,4-oxadiazoles 4a-4h were prepared starting from [bi-(4-fluorophenyl)-methyl]-piperazine under microwave irradiation with good yields. The technique of microwave irradiation proved to be an efficient, safe and environment-friendly technique with significant decreases in reaction time, comparably moderate yields, and easy manipulation. Furthermore, this method can be applied to the synthesis of many other oxadiazoles with more potential functional qualities. The structures of the eight compounds were determined by IR, MS and 1H NMR data. In the experiment, the researchers used many compounds, for example, 4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9Application In Synthesis of 4,4-Difluorobenzhydrylpiperazine).
4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Application In Synthesis of 4,4-Difluorobenzhydrylpiperazine
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics