Green methodologies in organic synthesis: microwave-assisted study on carbostyril derivatives under phase transfer catalysis was written by Kollapudi, Chandra Babu;Gutta, Madhusudhan;Reguri, Buchi Reddy. And the article was included in Heterocyclic Letters in 2015.Reference of 129722-25-4 This article mentions the following:
In this paper few carbostyril derivatives were synthesized by microwave method as well as by green chem. method. By applying the green synthesis method, not only avoided the use of DDQ and benzyl halide which is hazardous but also the formation of by products. The quaternary ammonium salts (PTC) under microwave conditions towards Aripiprazole (carbostyril derivative) act as a reagent and gave dehydrogenated and benzylated carbostyril from 3,4-dihydro carbostyril derivatives In the experiment, the researchers used many compounds, for example, 7-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)quinolin-2(1H)-one (cas: 129722-25-4Reference of 129722-25-4).
7-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)quinolin-2(1H)-one (cas: 129722-25-4) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Reference of 129722-25-4
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics