Effects of tandospirone citrate and oxazolam on pharmacokinetics of valproic acid following oral administration of sodium valproate to rats was written by Hobara, Norio;Kameya, Hiromasa;Hokama, Nobuo;Ohshiro, Susumu;Hobara, Narumi;Sakanashi, Matao. And the article was included in Iryo Yakugaku in 2007.Quality Control of rel-(3aR,4S,7R,7aS)-2-(4-(4-(Pyrimidin-2-yl)piperazin-1-yl)butyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione 2-hydroxypropane-1,2,3-tricarboxylate This article mentions the following:
The drug interactions between tandospirone citrate, a non-benzodiazepine antianxiety drug, and oxazolam, a minor benzodiazepine tranquilizer and antianxiety agent, and valproic acid (VPA), an anti-convulsant, were studied in rats. When tandospirone citrate or citric acid was administered orally immediately following oral administration (p.o.) of sodium valproate (VPA-Na), the plasma VPA levels were significantly lower than those in the control. In addition, pharmacokinetic parameters such as plasma VPA concentration and area under the plasma concentration-time curve up to 3 h (AUC) were significantly decreased. However, when tandospirone citrate was administered i.p., or both it and oxazolam were administered orally with VPA-Na, the VPA pharmacokinetic parameters were unchanged. These results suggest that decreases in plasma VPA concentrations (including those for AUC) may be due to a reduction in VPA-Na adsorption from the intestinal tract due to tandospirone citrate. In the experiment, the researchers used many compounds, for example, rel-(3aR,4S,7R,7aS)-2-(4-(4-(Pyrimidin-2-yl)piperazin-1-yl)butyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione 2-hydroxypropane-1,2,3-tricarboxylate (cas: 112457-95-1Quality Control of rel-(3aR,4S,7R,7aS)-2-(4-(4-(Pyrimidin-2-yl)piperazin-1-yl)butyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione 2-hydroxypropane-1,2,3-tricarboxylate).
rel-(3aR,4S,7R,7aS)-2-(4-(4-(Pyrimidin-2-yl)piperazin-1-yl)butyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione 2-hydroxypropane-1,2,3-tricarboxylate (cas: 112457-95-1) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Quality Control of rel-(3aR,4S,7R,7aS)-2-(4-(4-(Pyrimidin-2-yl)piperazin-1-yl)butyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione 2-hydroxypropane-1,2,3-tricarboxylate
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics