Hemiplegic migraine type 2 with new mutation of the ATP1A2 gene in Japanese cases was written by Oda, Ituki;Danno, Daisuke;Saigoh, Kazumasa;Wolf, Johanna;Kawashita, Norihito;Hirano, Makito;Samukawa, Makoto;Kitamura, Shigekazu;Kikui, Shoji;Takeshima, Takao;Mitsui, Yoshiyuki;Kusunoki, Susumu;Nagai, Yoshitaka. And the article was included in Neuroscience Research (Shannon, Ireland) in 2022.Electric Literature of C27H32Cl2F2N2O3 This article mentions the following:
We analyzed the clin. symptoms of hemiplegic migraine (HM) and their relevance in four Japanese patients considered to have ATP1A2 mutations as a cause. Sequencing of ATP1A2 was performed using the Sanger method in 43 blood samples from clin. suspected patients with familial HM. Subsequently, algorithm anal., allele frequency determination, and three-dimensional structure anal. of the recognized variants were performed, and the recognized variants were evaluated. We found four heterozygous missense mutations in ATP1A2 (Case 1: p.R51C; Case 2: p.R65L; Case 3: p.A269P; Case 4: p.D999H), three of which had not been reported to date. These four mutations may also affect the structure of the protein products, as assessed using a three-dimensional structural anal. In all four cases, the clin. symptoms included visual, sensory, motor, and verbal symptoms and the frequency and duration of headache attacks varied. Addnl., oral administration of a combination of lomerizine hydrochloride and topiramate had a partial effect in three cases. We report four missense mutations in ATP1A2. This report will be useful for the future anal. of mutations and clin. types in Asians, as well as Westerners, with migraine. In the experiment, the researchers used many compounds, for example, 1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7Electric Literature of C27H32Cl2F2N2O3).
1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Electric Literature of C27H32Cl2F2N2O3
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics