30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: To a solution of acid chloride 3a-b (1.0 equiv.), triethylamine (3.0 equiv.) in dry THF, was added arylpiperazines (1.2 equiv.) in dry THF dropwise. The mixture was stirred for 1 h at room temperature. The reaction mixture was diluted with EtOAc, washed with water and brine, dried over anhydrous MgSO4, and concentrated in vacuo. The crude product was purified by flash column chromatography on silica gel (EtOAC:hexanes = 1:1-1:5) to yield the desired products (4a-j). Compound 4i: 1H NMR (300 MHz, CDCl3) delta 7.52 (d, J = 8.5 Hz, 2H), 6.95 (d, J = 8.5 Hz, 2H), 3.95 (m, 4H), 3.37 (m, 4H), 2.79 (m, 4H), 1.80 (m, 4H).
As the paragraph descriping shows that 30459-17-7 is playing an increasingly important role.
Reference£º
Article; Song, Jiho; Lee, Kiho; Kim, Doran; Kim, Jongmin; Lee, Seul; Shin, Jun Seob; Kim, Dong-Seok; Min, Kyung Hoon; Bulletin of the Korean Chemical Society; vol. 35; 2; (2014); p. 666 – 668;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics