With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.
General procedure: A mixture of 3-(4-fluorophenylthio)propyl methanesulfonate (4b) (1.0 g, 3.79 mmol), 4-(4-chloro-phenyl)-piperidin-4-ol (0.8 g, 3.79 mmol), KI (120 mg), K2CO3 (1.2 g, 8.7 mmol) in DME (10 mL) was heated to reflux under N2 for 12 h. The cooled mixture was then diluted with EtOAc (400 mL) and washed with H2O (200 mL). The organic layers were pooled, dried with Na2SO4, and filtered. The filtrate was concentrated in vacuo, then followed by purification through column chromatography on silica gel, to afford 4-(4-chlorophenyl)-1-(3-((4-fluorophenyl)thio)propyl)piperidin-4-ol (6); yield 74%,
30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various.
Reference£º
Article; Peprah, Kwakye; Zhu, Xue Y.; Eyunni, Suresh V.K.; Setola, Vincent; Roth, Bryan L.; Ablordeppey, Seth Y.; Bioorganic and Medicinal Chemistry; vol. 20; 3; (2012); p. 1291 – 1297;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics