With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.122833-04-9,2-Methoxy-4-(4-methylpiperazin-1-yl)aniline,as a common compound, the synthetic route is as follows.
To n-butanol (2 mL) was added compound 4A-3 (30 mg, 0.135 mmol) and compound 5A-2 (47 mg, 0.135 mmol), and then p-toluenesulfonic acid (23.3 mg, 0.135mmol) was added under stirring. The mixture was heated to 100C and stirred for 5 hours. After TLC indicated the reaction was completed, the reaction mixture was concentrated under reduced pressure to give a crude product, which was further purified and isolated by column chromatography to obtain an off-white solid proudct, compound I-5 (59 mg, yield 81.8%). 1H NMR (400 MHz, cd3od) delta 9.09 (d, J=8.2 Hz, 1H), 8.33 (dd, J=4.3, 1.2 Hz, 1H), 8.09 (s, 1H), 7.54 (d, J=8.7 Hz, 1H), 7.48 (dd, J=8.7, 4.3 Hz, 1H), 6.67 (d, J=2.2 Hz, 1H), 6.54 (dd, J=8.7, 2.4 Hz, 1H), 3.89-3.73 (m, 4H), 3.27 (dd, J=9.3, 4.9 Hz, 4H), 2.89-2.73 (m, 4H), 2.49 (s, 3H), 1.30 (d, J=6.9 Hz, 6H). LCMS: t=0.662 min, 532.3 (M), 534.3 (M+1)., 122833-04-9
As the paragraph descriping shows that 122833-04-9 is playing an increasingly important role.
Reference£º
Patent; Humanwell Healthcare (Group) Co., Ltd.; WANG, Xuehai; XU, Yong; SHENG, Xijun; ZHANG, Xiaolin; XIA, Hangui; YANG, Zhongwen; YUE, Yang; HUANG, Lu; XIAO, Qiang; (80 pag.)EP3372594; (2018); A1;,
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