With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.112984-60-8,6-Fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid,as a common compound, the synthetic route is as follows.
To a stuffed solution of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC.HC1, 575 mg, 3.0 mmol) in DMF at 0 C,2-picolinic acid (246 mg, 2.0 mmol) was added followed by addition of hydroxybenzotriazole(HOBt, 405 mg, 3.0 mmol) and the final reaction mixture was stuffed at 0C. After 30 mm 6-fluoro-1- methyl-4-oxo-7-(piperazin- 1 -yl)- 1 H,4H- [1,3] thiazeto[3 ,2-a] -quinoline-3 -carboxylic acid (700 mg, 2.01 mmol) and N,N-diisopropylethylamine(0.53 ml, 3 mmol) were added and reaction mixture was allowed to stir at room temperature for overnight. After completion, the reaction mixture wasevaporated, remaining mass was triturated 2-3 times and dried to obtain compound 3las an off white solid (250 mg, 28%). 1H NMR (DMSO-d6): oe 14.61 (brs, 1H, COOH), 8.62 (d, 1H, JAB = 4.5 Hz, ArH), 7.96 (t, 1H, JAB = 7.5 Hz, ArH), 7.82 (d, 1H, JAB = 13.5 Hz, ArH), 7.64 (d, 1H, JAB = 7.5 Hz, ArH), 7.52 (dd, 1H, JAB = 7.0 Hz, Jm = 5.0 Hz, ArH), 6.98 (d, 1H, JAB = 7.0 Hz, ArH), 6.36 (q, 1H, JAB = 6.0 Hz,SCHN), 3.89-3.81 (m, 2H, CH2N), 3.66-3.52 (m, 2H, C?H2N), 2.11 (d, 3H, JAB = 6.5Hz, CH3). ESI-MS (mlz): 454.92 (M+H)., 112984-60-8
As the paragraph descriping shows that 112984-60-8 is playing an increasingly important role.
Reference£º
Patent; VYOME BIOSCIENCES PVT. LTD.; SENGUPTA, Shiladitya; GHOSH, Shamik; GHOSH, Sumana; SINHA, Mau; SADHASIVAM, Suresh; BHATTACHARYYA, Anamika; MAVUDURU, Siva Ganesh; TANDON, Nupur; KUMAR, Deepak; (149 pag.)WO2017/17631; (2017); A2;,
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