59878-57-8,59878-57-8, 1-(Cyclopropylcarbonyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
The synthetic route is: Piperazine cyclopropyl ketone (1.1g, 0.0071mol)Soluble in 25ml anhydrous acetonitrile,Add potassium carbonate (4.0g, 0.029mol), cool to 0 , nitrogen protection,Stir vigorously. Compound 5 (2.1g, 0.0066mol),Dissolve with 20ml of anhydrous acetonitrile and slowly add dropwiseAfter the addition, the temperature was raised to room temperature, a small amount of DMAP (0.5g, 0.0041mol) was added, and the reaction was carried out for 6h.Concentrate under reduced pressure, add 40ml of water, adjust the pH to 8 with sodium bicarbonate, extract with ethyl acetate, concentrate under reduced pressure to remove the solvent, recrystallize with ethyl acetate, filter to obtain light red solid, decolorize with a small amount of activated carbon, filter and concentrate It was dried to obtain a white solid (2.8g, yield 93%).
The synthetic route of 59878-57-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Southeast University; Cai Jin; Ren Jinghui; Hu Xinyi; Wei Lili; Yu Ping; Huang Mingqi; (8 pag.)CN110790710; (2020); A;,
Piperazine – Wikipedia
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