With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1228780-72-0,1-((4′-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazine,as a common compound, the synthetic route is as follows.
1-( ( 4′-chloro-S ,S-dimethyl-3 ,4,S,6-tetrahydro-[ 1,1 ‘-bipheny 1]-2-yl)methyl)piperazine(12.3 g) was dissolved in dimethyl sulfoxide (8S mL) under nitrogen atmosphere and added dibasic potassium phosphate (20.6 g) at 29C and stirred for 5 minutes at the sametemperature. Methyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-fluorobenzoate (8.5 g) wasadded to the reaction mixture at at 29C and stirred for 5 minutes at the same temperature.Heated the reaction mixture to 120C and stirred for 24 hours at the same temperature.The reaction mixture was cooled to 30C and quenched with cold water (255 mL) slowlyin 20 minutes. The reaction mixture was stirred for 30 minutes at the 30C and filtered.The compound was dissolved in ethyl acetate (85 mL) and washed with saturated aqueoussodium bicarbonate (2 x 50 mL) and brines solution (25 mL). The separated organic layerwas dried over sodium sulfate and evaporated the solvent completely to obtain crudecompound. The crude compound was purified by column chromatography using 60-120silica gel mesh and 60% ethyl acetate – hexane as eluent followed by recrystallization indiethyl ether and petroleum ether to obtain title compound as white solid. Yield: 11.4 g;Purity by HPLC: 99.052%
1228780-72-0, The synthetic route of 1228780-72-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; DR. REDDY?S LABORATORIES LIMITED; PEDDIREDDY, Subba Reddy; KOTTUR, Mohan Kumar; JURUPULA, Ramprasad; BAIG, Mohammed Azeezulla; CHAKKA, Ramesh; THIPPARABOINA, Rajesh; PEDDY, Vishweshwar; RAO, Pallavi; ORUGANTI, Srinivas; DAHANUKAR, Vilas Hareshwar; (88 pag.)WO2017/212431; (2017); A1;,
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