325145-35-5, (S)-tert-Butyl 2-ethylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
325145-35-5, Example 2J kJlBOCA 250 ml round bottom flask was charged with A2 (4g, 15.9 mmol), 1-Boc-2-S-ethyl piperazine A3 (prepared as per Kiley et al Org. Prep. Proc. Int. 1990, 22, 761; 4.2 g, 18.6 mmol), tris(dibenzylideneacetone)dipalladium , (340 mg, 0.37 mmol), racemic-2,2′-bis(diphenylphosphino)-1 ,1′-binaphthyl (BINAP) (495 mg, 0.74 mmol), cesium carbonate (12g, 37.2 mmol) and toluene (80 ml). After the mixture was heated at 1003C for 16 h, fresh tris(dibenzylidene- acetone)dipalladium (340 mg, 0.37 mmol) and BINAP (495 mg, 0.74 mmol) were added and the heating was continued for 3 days. The solvent was removed in vacuo, and the residue was suspended in a 100 ml portion of ethyl acetate. This mixture was extracted with water and brine, dried over sodium sulfate, and concentrated in vacuo. Purification of the residue via silica gel flash chromatography (5percentmethanol/ 95percent DCM) yielded 5.3 g of a partially purified material which was used directly in the next step. M+H = 350
The synthetic route of 325145-35-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SCHERING CORPORATION; PHARMACOPEIA, INC.; WO2008/8453; (2008); A1;,
Piperazine – Wikipedia
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