848482-93-9, (S)-4-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A solution of octanal (0.68 mL, 4.3 mmol) in tetrahydrofuran (2 mL) was added to a stirred solution of (S)-piperazine-l , 3-dicarboxylic acid 1-tert-butyl ester (1.0 g, 4.3 mmol) in tetrahydrofuran (1 15 mL). Acetic acid (0.9 mL, 15.8 mmol) was added to the solution. After stirring the reaction mixture for 30 minutes, sodium triacetoxyborohydride (1.37 g, 6.5 mmol) was added in portions over 5 minutes and the mixture stirred for 18h. The mixture was then filtered through Celite and the filtrate evaporated to an oil (1.47 g). The oil was stirred with diethyl ether (20 mL) and the insoluble solid was filtered off and purified by column chromatography over silica gel, eluting with a gradient of methanol/ethyl acetate to give the title compound as a white solid (287 mg, 0.84 mmol, 19%), m/z 343 (MuEta ‘ ). C18H34N2O4 exact mass 342.25., 848482-93-9
The synthetic route of 848482-93-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; NEW PHARMA LICENCE HOLDINGS LIMITED; BROWN, Pamela; DAWSON, Michael; SIMONOVIC, Mona; BOAKES, Steven; DUPERCHY, Esther; STANWAY, Steven James; WILSON, Antoinette; MOSS, Stephen Frederick; WO2015/135976; (2015); A1;,
Piperazine – Wikipedia
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