With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.78818-15-2,Benzyl 3-oxopiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
Preparation No.13: 5-Methoxy-3,6-dihydro-2H-pyrazine-l-carboxylic acid benzyl ester; A solution of benzyl 3-oxopiperazine-l-carboxylate (2.50g, 10.67 mmol) in CH2Cl2 (100 ml) was cooled to 0 0C and treated with Na2CO3 (23.0 g, 217 mmol) for 10 minutes. Neat trimethyloxonium tetrafluoroborate (5.50 g, 37.2 mmol) was added in one portion, then the reaction is allowed to warm to room temperature for 6 hours. The reaction was poured into water (100ml), and the layers were separated. The aqueous layer was re-extracted aqueous with 50ml CH2Cl2 and the combined organic layers were washed with brine (100ml). The organic layer was dried over sodium sulfate, filtered and concentrated to yield 5-methoxy-3,6- dihydro-2H-pyrazine-l -carboxylic acid benzyl ester (2.51g, 95%) as an oil. LCMS (Table 1, Method a) R1 = 3.00 min, m/z 249.24 (M+H)+”; 1H NMR (400 MHz, DMSO-d6) delta 7.36 (m, 5H), 5.16 (s, 2H), 3.96 (s, 2H), 3.68 (s, 3H), 3.54 (s, 2H), 3.47 (m, 2H)
78818-15-2, The synthetic route of 78818-15-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ABBOTT LABORATORIES; WO2008/76356; (2008); A1;,
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