120737-78-2, tert-Butyl 2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a greenhouse test tube was added rac-benzyl ((2S,3R,4R)-1-acetyl-6-bromo-2-cyclopropyl-3- methyl-I ,2,3,4-tetrahydroq uinolin-4-yl)carbamate (for a preparation see Intermediate 3, 101 mg,0.234 mmol), sodium tert-butoxide (65 mg, 0.676 mmol), DavePhos (18.1 mg, 0.046 mmol),Pd(dba)3 (21.9 mg, 0.024 mmol) and 1,4-dioxane (2 mL). tert-Butyl 2-methylpiperazine-1- carboxylate (0.070 mL, 0.351 mmol) was then added and the reaction mixture stirred at 100 C for 20 h 45 mm. The reaction mixture was allowed to cool to rt and then filtered through a pad of celite and rinsed with ethyl acetate. The filtrate was concentrated and purified by MDAP (Formic) to give the product (14.1 mg, 0.034 mmol, 14.46%) as a pale yellow gum. This was a racemic mixture ofdiatereoisomers. LCMS (2 mm Formic): Rt = 0.77 mi [MH] = 417.
120737-78-2, The synthetic route of 120737-78-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; AMANS, Dominique; ATKINSON, Stephen John; HARRISON, Lee Andrew; HIRST, David Jonathan; LAW, Robert Peter; LINDON, Matthew; PRESTON, Alexander; SEAL, Jonathan Thomas; WELLAWAY, Christopher Roland; WO2014/140076; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics