115761-79-0, 1-(2,4-Difluorophenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Take 50mL one-mouthed flask, were successively added 2-(1-methylcyclopropyl)methoxy-5-(methylsulfonyl)benzoic acid (50mg, 0.19mmol), 1-(2,4-difluorophen-1-yl)piperazine (36mg, 0.18mmol), HATU (108mg, 0.29mmol), TEA (0.10mL, 0.66mmol), DMF (10mL), the reaction at room temperature overnight, saturated sodium chloride (20 mL), and extracted with ethyl acetate (20mL * 3), the organic phase with anhydrous sodium sulfate, and concentrated to dryness to give a crude product, after reverse phase preparative chromatography crude was pure 35mg, yield: 42%., 115761-79-0
115761-79-0 1-(2,4-Difluorophenyl)piperazine 2734637, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; Shanghai Hansoh BioMedical Co., Ltd.; Jiangsu Stockhausen Pharmaceutical Group Co., Ltd.; Liao, Jianchun; Yu, Hongping; Xu, Yaochang; Chen, Jianghua; Zhang, Shaobao; Xiu, Wenhua; Liu, Zhaomin; (48 pag.)CN105712952; (2016); A;,
Piperazine – Wikipedia
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