34770-60-0, 4-Methylpiperazin-2-one is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
(i) 2-Methoxy-4-(4-methyl-2-oxopiperazin-l-yl) benzaldehvde To a solution of 4-bromo-2-methoxybezaldehyde (10.0 g, 46.5 mmol) in 1 ,4-dioxane (140 mL) was added Cul (8.84 g, 46.5 mmol), N,N’-dimethyldiaminoethane (10.0 mL, 93.0 mmol), 4-methylpiperazin-2-one (7.95 g, 69.8 mmol), and Cs2C03 (45.0 g, 139 mmol). The mixture was heated to 100C and stirred for 5h. After cooling, the mixture was filtered, and the solution was adjusted to pH 2~3 with IN HCl. After stirring for 3h at r.t., the mixture was neutralized with sat. aq. NaHC03,and the resulting mixture was extracted with EtOAc. The combined organic solutions were washed with brine, and then dried (Na2S04). After removal of the solvent in vacuo, the subtitle compound was obtained as a white solid (10.7 g, 43.1 mmol, 93%); NMR: 10.4 (1H, s), 7.86 (1H, d), 7.1 1 (1 H, d), 6.92 (1H, dd), 3.92 (3H, s),3.76 (2H, t), 3.30 (2H, s), 2.82 (2H, t), 2.42 (3H, s); LC-MS: m/z = 249 [MH+] (T = 0.92 min).
34770-60-0, The synthetic route of 34770-60-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Dainippon Sumitomo Pharma Co., Ltd.; ASTRAZENECA AKTIEBOLAG; TOSAKI, Shinya; HORI, Seiji; WO2012/67268; (2012); A1;,
Piperazine – Wikipedia
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