Electric Literature of 5308-25-8, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 5308-25-8, Name is 1-Ethylpiperazine, SMILES is CCN1CCNCC1, belongs to piperazines compound. In a article, author is Ciammaichella, Alina, introduce new discover of the category.
Optimization of 2-(1H-imidazo-2-yl)piperazines series of Trypanosoma brucei growth inhibitors as potential treatment for the second stage of HAT
A previous publication from our laboratory reported the identification of a new class of 2-(1H-imidazo-2-yl) piperazines as potent T. brucei growth inhibitors as potential treatment for Human African Trypanosomiasis (HAT). This work describes the structure-activity relationship (SAR) around the hit compound 1, which led to the identification of the optimized compound 18, a single digit nanomolar inhibitor (EC50, 7 nM), not cytotoxic and with optimal in vivo profile that made it a suitable candidate for efficacy studies in a mouse model mimicking the second stage of disease.
Electric Literature of 5308-25-8, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 5308-25-8 is helpful to your research.
Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics