A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 111974-74-4, Name is 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride, molecular formula is C17H19Cl2N3S. In an article, author is Malasala, Satyaveni,once mentioned of 111974-74-4, HPLC of Formula: C17H19Cl2N3S.
Copper mediated one-pot synthesis of quinazolinones and exploration of piperazine linked quinazoline derivatives as anti-mycobacterial agents
A facile method was developed for the synthesis of quinazolinone derivatives in a one-pot condensation reaction via in situ amine generation using ammonia as the amine source and with the formation of four new C-N bonds in good to excellent yields. With the optimised method, we synthesized a library of piperazine linked quinazoline derivatives and the synthesized compounds were evaluated for their inhibitory activity against Mycobacterium tuberculosis. The compounds 8b, 8e, 8f, 8m, 8n and 8v showed potent anti-mycobacterial activity with MIC values of 2-16 mu g mL(-1). All the synthesized compounds follow Lipinski’s rules for drug likeness.
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Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics