The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 300543-56-0, Name is (R)-1-((4-Chlorophenyl)(phenyl)methyl)piperazine, SMILES is ClC1=CC=C([C@H](N2CCNCC2)C3=CC=CC=C3)C=C1, in an article , author is Wang, Apeng, once mentioned of 300543-56-0, Category: piperazines.
Design, synthesis and antimycobacterial activity of new benzothiazinones inspired by rifampicin/rifapentine
A series of novel benzothiazinone derivatives containing a N-((methylene)amino)piperazine moiety, inspired by rifampicin/rifapentine, were designed and synthesized. Seven compounds 1a and 1e-j show excellent in vitro activity against both drug-sensitive MTB strain H37Rv and drug-resistant clinical isolates (MIC: 0.029-0.110 mu M), and accepted selective index (1100 – > 4000). Compound 1h displays good safety and pharmacokinetic profiles, suggesting its promising potential to be lead compound for future antitubercular drug discovery.
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Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics