With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.129799-15-1,Methyl 1-Boc-piperazine-2-carboxylate,as a common compound, the synthetic route is as follows.
4-Chloro-6-(3,4-dichloro-phenyl)-pyrimidine (0.1 lg, 0.4mmol) was added in one portion to a suspension of piperazine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester (0.21g, 0.85mmol) and in fert-butanol (2ml) in a microwave reactor tube. The tube was sealed and heated to 150C in a microwave for 40 minutes at a pressure of 250psi. After this time the reaction mixture was cooled to room temperature and the solvent was removed. The resulting residue was purified by flash column chromatography (elution: 20% EtOAc, 80% Heptane) to give the title compound (0.36g, 75% yield) as a colourless oil. deltaEta (500 MHz, DMSO) 8.59 (s, 1 H) 8.43 (d, J=2.05 Hz, 1 H) 8.17 (dd, J=8.51, 2.05 Hz, 1 H) 7.74 – 7.81 (m, 1 H) 7.42 (d, J=7.88 Hz, 1 H) 4.88 – 5.09 (m, 1 H) 4.60 – 4.76 (m, 1 H) 4.24 – 4.46 (m, 1 H) 3.76 – 3.88 (m, 1 H) 3.56 (d, J=13.08 Hz, 3 H) 3.38 – 3.51 (m, 1 H) 3.10 – 3.28 (m, 2 H) 1.31 -1.47 (m, 9 H). Tr = 3.71 min m/z (ES+) (M+H+) 283, 285.
129799-15-1, 129799-15-1 Methyl 1-Boc-piperazine-2-carboxylate 2756818, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; DOMINGUEZ, Celia; TOLEDO-SHERMAN, Leticia, M.; COURTNEY, Stephen, Martin; PRIME, Michael; MITCHELL, William; BROWN, Christopher, John; DE AGUIAR PENA, Paula, C.; JOHNSON, Peter; WO2013/16488; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics