5271-27-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5271-27-2,1-Methyl-3-phenylpiperazine,as a common compound, the synthetic route is as follows.
Example 7 Preparation of Piperazine Derivative To 11 ml of dimethylformamide were added 5.51 g (31.3 mmol) of 1-methyl-3-phenylpiperazine obtained in Example 6, 4.47 g (31.3 mmol) of 2-chloro-3-cyanopyridine, 4.1 g (31.3 mmol) of triethylamine and 5.20 g (31.3 mmol) of potassium iodide, and the resulting mixture was reacted at 125 to 130 C. for 24 hours in nitrogen gas atmosphere. Next, triethylamine and dimethylformamide were distilled off from the reaction mixture under reduced pressure, and thereafter 20 ml of water and 25 ml of ethyl acetate were added to the resulting mixture. The pH of the reaction mixture was adjusted to 8 to 9 with a 10% aqueous sodium hydroxide. The mixture was allowed to separate into two layers. Thereafter, the aqueous layer was extracted twice with 30 ml of ethyl acetate, and the organic layers were combined together. The combined organic layer was washed with 5% aqueous sodium hydrogencarbonate. The organic layer was dried over anhydrous magnesium sulfate and concentrated. The residue was crystallized from petroleum ether, to give 3.14 g of pale yellow 2-(4-methyl-2-phenylpiperazin-1-yl)-3-cyanopyridine (yield based on 1-methyl-3-phenylpiperazine: 36%, melting point: 65.7 to 66.8 C.). Its HPLC purity was 97.1%.
5271-27-2 1-Methyl-3-phenylpiperazine 2760009, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; Sumika Fine Chemicals Co., Ltd.; US6495685; (2002); B1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics