438631-77-7, 438631-77-7 (R)-1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate 6558432, apiperazines compound, is more and more widely used in various fields.
438631-77-7, (R)-1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Representative Synthesis I; (R)-l-(4-Chloro-benzyl)-piperazine-2-carboxylic acid methyl ester; R-4N-Boc-piperazine 2-carboxylic acid methyl ester (679.4mg, 2.78mmol) and 4- chlorobenzaldehyde (390.94mg, 2.78mmol) are mixed in dichloromethane(lthetaml) for 30 minutes. Sodium triacetoxyborohydride (800mg, 3.77mmol) is added. The mixture is stirred at room temperature for 16 hf . Water is added. The aqueous layer is extracted with dichloromethane twice (3OmL x2). The dichloromethane solution is treated with trifluoracetic acid (30ml). After 4 hrs the solvent is evaporated and re-disolved in water. The water solution is basified by adding K2CO3 (solid). The water solution is extracted with EtOAc three times. The organic layer is dried over NaSO4. The product is colorless oil (748mg, 100% ) after removing solvent to dryness. Found reta/z ES+=269 . ‘ . .
438631-77-7, 438631-77-7 (R)-1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate 6558432, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; NOVARTIS AG; NOVARTIS PHARMA GmbH; WO2007/120595; (2007); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics