With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1235865-77-6,2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4′-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid,as a common compound, the synthetic route is as follows.
A solution of sodium-2-ethylhexenoate (0.32 g) in ethyl acetate (5 mL) was added to a mixture of 2-((lH-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4′-chloro-5, 5-dimethyl-3,4,5,6-tetrahydro[l,l’-biphenyl]-2-yl)methyl)piperazin-l-yl)benzoic acid (1.0 g) in ethyl acetate (5 mL) and stirred at 20-30 degree Celsius. The resulting slurry was filtered, washed with ethyl acetate (5 mL) and the solid was dried under vacuum at 50- 55 degree Celsius for 16 h to furnish sodium 2-((lH-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4- (4-((4′-chloro-5,5-dimethyl-3,4,5,6-tetrahydro[l,r-biphenyl]-2-yl)methyl)piperazin-l- yl)benzoate. Yield: 57.80% (0.6g) HPLC Purity: 96.97% 1H NMR (DMSO-d6): d q.93 (s, 6H), 1.37 (t, J= 6.4 Hz, 2H), 1.96 (s, 2H), 2.16 (t, br, 2H) 2.21 (m, 4H), 2.73 (s, 2H), 2.97 (s, 4H), 6.26 (dd, J=2.0, 1.2 Hz, 2H), 6.57 (dd, J=L6, 2.0, Hz, 1H), 7.05 (d, J=8.4, 2H), 7.29 (d, J=2.8 Hz, 1H), 7.34 (d, J=8.4 Hz, 2H), 7.38 (t, J=2.8 Hz, 1H), 7.45 (d, J=8.8 Hz, 1H), 7.94 (d, J=2.8 Hz, 1H), 11.49 (s, 1H, NH).
1235865-77-6 2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4′-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid 66713100, apiperazines compound, is more and more widely used in various.
Reference£º
Patent; FRESENIUS KABI ONCOLOGY LTD.; GUPTA, Chandan Kumar; DHIMAN, Navdeep; SANGHANI, Sunil; SINGH, Govind; LAHIRI, Saswata; CABRI, Walter; GUPTA, Nitin; (0 pag.)WO2020/3272; (2020); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics