With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59878-57-8,1-(Cyclopropylcarbonyl)piperazine,as a common compound, the synthetic route is as follows.,59878-57-8
(4-fluoro-3-carboxybenzyl) thieno [2,3-D] pyrimidine-2,4 (1H, 3H) -dione (0.21 g, 0.66 mmol), tripyrrolidinium bromide phosphonium hexafluorophosphate (PyBrOP, 0.46 g, 0.99 mmol), 1-cyclopropanecarbonylpiperazine (0.1 g, 0.66 mmol), N, N-diisopropylethylamine (DIPEA, 0.17 g, 1.32 mmol), Dichloromethane (5 mL) was added to the reaction flask and stirred at room temperature overnight. The reaction solution was added with methylene chloride (5 mL) Water (5 mL), extracted and the organic layer washed with water (3 mL), dried, filtered and concentrated to give the crude product. The crude product was purified by silica gel column chromatography (mobile phase CH2Cl2 / CH3OH 50/1) The final product, 1- (4-fluoro-3- (4-cyclopropylcarbonylpiperazine- 1 -carbonyl) benzyl) thieno [2,3- D] pyrimidine-2,4 (1H, 3H) dione (I-2), a white solid (0.19 g, yield 63.3%),
As the paragraph descriping shows that 59878-57-8 is playing an increasingly important role.
Reference£º
Patent; Shanghai Xunhe Pharmaceutical Technology Co., Ltd.; Zheng Yongyong; Jin Hua; Zhou Feng; Huang Meihua; Meng Xin; (28 pag.)CN107286174; (2017); A;,
Piperazine – Wikipedia
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