With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31166-44-6,1-Cbz-Piperazine,as a common compound, the synthetic route is as follows.
31166-44-6, To a solution of benzyl piperazine-1 -carboxylate (1 .10 g, 4.99 mmol) and 1 -bromo-3-diethoxyphosphoryl-propane (1 .29 g, 4.99 mmol) in CH3CN (40.00 mL) was added K2003 (1 .38 g, 9.98 mmol). The reaction mixture was stirred at 75 00 overnight and then EtOAc (50 mL) and water (30 mL) were added. The layers were separated, and the aqueous phase was extracted again with EtOAc (20 mLx2). The combined organic phases were washed with brine (40 mL), dried over anhydrous Mg504, filtered andconcentrated. The residue was purified by flash column chromatography on silica gel to afford Compound 15.la (EtOAc/MeOH=50:1) to afford (1.80 g, 4.52 mmol, 91percent yield) as an oil. 1H NMR (400 M, ODd3), oe7.35 (m, 5H), 5.13 (s, 2H), 4.12 (m, 4H), 3.52 (m, 4H), 2.42 (m, 6H), 1.78 (m, 4H), 1.32 (m, 6H).
31166-44-6 1-Cbz-Piperazine 643495, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; UNITY BIOTECHNOLOGY, INC.; BACKES, Bradley; W. VON GELDERN, Thomas; CHEN, Bing; (121 pag.)WO2017/101851; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics