With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20327-23-5,1-Cyclopropylpiperazine,as a common compound, the synthetic route is as follows.
40 mg of compound III and 56 mg of cyclopropylpiperazine, 2 drops of glacial acetic acid were added to 5 ml of anhydrous methanol, stirred, heated to 60 C, and reacted for 4 hours.Then, 50 mg of sodium cyanoborohydride (NaBH3CN) was added and reacted at room temperature for 12 hours.TLC monitoring, antiAfter completion, the solvent was evaporated, the reaction was poured into 100 mL of water, and extracted with ethyl acetate (20 mL¡Á3),The phases were washed with 5% NaHCO 3 (20 mL¡Á3), saturated brine (20 mL¡Á3), and dried over anhydrous magnesium sulfate.Filtration, removal of ethyl acetate under reduced pressure, followed by column chromatography V (dichloromethane):V (methanol) = 20:1 gave white solid compound C7 8 mg., 20327-23-5
As the paragraph descriping shows that 20327-23-5 is playing an increasingly important role.
Reference£º
Patent; Southern Medical University; Chen Jianjun; Cheng Binbin; (23 pag.)CN109503546; (2019); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics