With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13484-40-7,1-(2-Methoxyethyl)piperazine,as a common compound, the synthetic route is as follows.
A solution of (i?)-3-(6-(2- fluorophenyl)-5,6-dihydrobenzo[h]quinazolin-2-ylamino)phenethyl methanesulfonate (5.37 g, 11.00 mmol), l-(2-methoxyethyl)piperazine (3.32 niL, 22.34 mmol) and triethylamine (1.5 niL, 11.17 mmol) in JV,JV-dimethylacetamide (30 mL) was heated at 90 0C for 20 h. After cooling to room temperature, water (200 mL) was added while stirring. The suspension was stirred for 15 min. and filtered. Solid was taken into dichloromethane (200 mL), dried over sodium sulfate and concentrated. Product was purified by flash column chromatography on silica gel (120 g silica gel column, 0-10% 7N NH3 in methanol-dichloromethane, over 80 min.) to afford the title compound as a yellow solid (5.50 g, 93% yield). 1H-NMR (DMSO- d6): delta 9.53 (s, 1 H), 8.37-8.34 (m, 1 H), 8.33 (s, 1 H), 7.81 (s, 1 H), 7.62-7.60 (m, 1 H), 7.51- 7.46 (m, 2 H), 7.30-7.19 (m, 3 H), 7.08-7.02 (m, 2 H), 6.82-6.79 (m, 2 H), 4.67 (t, J= 7.2 Hz, 1 H), 3.41 (t, J= 5.6 Hz, 2 H), 3.22-3.08 (m, 2 H), 3.33 (s, 3 H), 2.74-2.70 (m, 2 H), 2.59- 2.42 (m, 12 H). LCMS m/e 539 [M+H].
13484-40-7, As the paragraph descriping shows that 13484-40-7 is playing an increasingly important role.
Reference£º
Patent; ARQULE, INC.; ALI, Syed, M.; ASHWELL, Mark; TANDON, Manish; YANG, Rui-yang; LIU, Yanbin; VENSEL, David; EATHIRAJ, Sudharshan; PALMA, Rocio; LAPIERRE, Jean-marc; WESTLUND, Neil; WU, Hui; NAMDEV, Nivedita; KELLEHER, Eoin; KELLEHER, Eugene; WO2010/78421; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics