With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.162046-66-4,4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)benzoic acid,as a common compound, the synthetic route is as follows.
116a) tert-butyl 4-{4-[(dimethylamino)carbonyl]phenyl}piperazine-1-carboxylate; After 1,1′-carbonyldiimidazole (0.58 g, 3.6 mmol) was added to tetrahydrofuran (10 mL) solution of 4-[4-(tert-butoxycarbonyl)piperazin-1-yl]benzoic acid (1.00 g, 3.3 mmol) and the mixture was stirred at room temperature for 30 minutes, 50% dimethylamine aqueous solution (0.45 mL) was added. The reaction liquid was stirred at room temperature for four hours and a saturated saline solution (100 mL) and ethyl acetate (100 mL) were added and partitioned. The organic layer was washed with a saturated sodium carbonate aqueous solution (30 mL) and the solvent was evaporated under reduced pressure after drying over sodium sulfate. The residue was purified by silica gel column chromatography (100% ethyl acetate) and 1.00 g of the title compound was obtained (yield 92%). Mp 126-128C; IR (KBr) numax 1689, 1628, 1241, 1165, 835, 769 cm-1; 1H NMR (CDCl3, 400MHz) delta 1.49 (9H, s), 3.06 (6H, brs), 3.20 (4H, t, J = 5.1 Hz), 3.58 (4H, t, J = 5.1 Hz), 6.89 (2H, d, J = 8.6 Hz), 7.38 (2H, d, J = 8.6); MS (FAB) m/z: 333 [M+]; Anal. Calcd for C18H27N3O3: C, 64.84; H, 8.16; N, 12.60. Found: C, 64.82; H, 8.41; N, 12.59., 162046-66-4
162046-66-4 4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)benzoic acid 2795508, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; Sankyo Company, Limited; EP1764367; (2007); A1;,
Piperazine – Wikipedia
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